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In overdose, it is well established to be hepatotoxic

The work of the authors is supported by grants from the European Union 7th Framework Programme (FP7) projects FP7- HEALTH.2012.2.4.5-2 Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases 305815 (A.M.) and Marie Skodowska-Curie scheme FP7-PEOPLE-2013-IEF CHONDRION 625746 (A.M.)

Cystic fibrosis Although SubP stimulates gland secretion in normal submucosal glands, reports suggest that it is ineffective in people with CF [76]

J Physiol Pharmacol 60(Suppl 7):107114 Ilic S, Drmic D, Zarkovic K et al (2010) High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats