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For context on what's expected with legitimate GLP-1 therapy and what crosses into urgent territory, see our guide on GLP-1 side effects and when to call a clinician

Sharma S, Lustig RH, Fleming SE: Identifying metabolic syndrome in overweight and obese African-American children using fasting HOMA-IR in place of glucose

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In this randomised, double-blind, placebo-controlled study, adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity but without type 2 diabetes received retatrutide or placebo over 48 weeks