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In the Phase 2 obesity trial (NEJM, 2023), participants were assigned to different dose arms with varying escalation schedules

"They can lead to substantial weight loss when used in conjunction with healthy lifestyle changes in people who are overweight or have obesity with or without type 2 diabetes," says Dr

J Endocrinol Investig 19:433440 Muoz MT, Barrios V, Pozo J, Argente J (1996) Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications

Greasy or fried foods tend to make stomach-related side effects worse because they slow digestion even further