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09Clinical limits and treatment boundaries No GLP-1 receptor agonist carries an FDA indication for alcohol use disorder, and prescribing one specifically to reduce drinking is off-label

The results of long-term safety studies and cardiovascular end point studies will determine the future role of these drugs

Abstract Along the obesity pandemic, the prevalence of non-alcoholic fatty liver disease (NAFLD), often regarded as the hepatic manifestation of the metabolic syndrome, increases worldwide representing now the prevalent liver disease in western countries

Semaglutide has also demonstrated impressive results, with 59% NASH resolution in a phase 2 trial and substantial reductions in hepatic fat content measured by MRI