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A recent study has revealed that albuminuria can activate the Wnt/-catenin signaling pathway in renal TECs, promoting the expression of TLR4/NLRP3-associated chemokines and inflammatory factors, thereby causing renal tubular and tubulointerstitial inflammation ( In summary, when the body is subjected to various injuries and stimuli, the inflammatory response is activated, and cytokines released by inflammatory cells can cause apoptosis, cellular dysfunction, oxidative stress, and increased expression of cell adhesion molecules in renal tubular epithelial cells, leading to structural and functional damage to the renal tubules

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