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Additionally, our study relied on AEs documented in the medical record, whereas both the PIONEER and SUSTAIN trials conducted formal adverse drug reaction screenings, which could explain the large difference in reported AEs and contribute to the absence of AEs seen within the oral semaglutide 14-mg group

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Its mechanism of action is primarily mediated by its role as a substrate for NAD + -dependent enzymes such as the sirtuin family (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and certain ectoenzymes like CD38 and CD157

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