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To take advantage of the unique properties of pancreatic beta cells, we constructed 3rd generation lentiviral vectors carrying insulin promoter connected to the insulin gene (LentiINS) targeting pancreatic beta cells

doi: 10.1083/jcb.202010053 58 ZhangQLiuZWangQLiX

It is much better to take a smaller, highly bioavailable dose that your cells can actually use

Transdermal delivery via iontophoresis has also been studied, with a 2017 investigation demonstrating successful delivery of KPV across microporated human skin.11 Subcutaneous injection: Used in animal studies for systemic inflammation