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In ovariectomy (OVX)-induced osteoporosis in aged rats, exendin-4 enhanced bone strength and prevented exacerbation in trabecular microarchitecture ( The Impact of GLP-1 on Bone Fractures The relationship between GLP-1 and the risk of bone fractures has not been fully elucidated

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By analyzing the geometry, energetics, and prevalence of each interaction type, we highlight how structural information can guide rational lead optimization