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Factors That Control Your Individual Weight Loss Speed Six primary factors determine how fast you lose weight on GLP-1 therapy: starting body weight, genetic predispositions in appetite-regulation pathways, concurrent diet quality, exercise consistency, medication dosage titration, and metabolic health markers like insulin resistance baseline

What matters most isn't comparing yourself to a chartit's how you feel, how your levels have changed over time, and whether your symptoms align with what your numbers show

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but food joy is missed The emotional disconnect is one of the most surprising and profound side effects of GLP-1 use