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Introduction Glutathione is a tripeptide found in many tissues at relatively high concentrations, namely 110 mM in cells, similarly to glucose, potassium, and cholesterol, with a critical role in several physiological processes, such as redox balance preservation, reduction of oxidative stress through detoxification from xenobiotic and endogenous compounds, and immune system modulation ( Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases ( Although the pathogenic role of oxidative stress in NAFLD pathogenesis is well established ( 2