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The results showed a significant decrease in mean body weight, with a reduction of 12.1% compared to the placebo group

In individuals with obesity without T2DM, SURMOUNT- 1 evaluated the safety and effectiveness of tirzepatide 5, 10, and 15 mg once weekly in comparison to a placebo when paired with a 500 kcal/day deficit diet and recommendations for 150 min of weekly exercise [118]

Research suggests that GLP-1 medications may also influence brain pathways involved in addiction, including those related to reward processing, cravings, and stress