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Given that DPP-IV cleavage of GLP-1 736 amide generates GLP-1 936 amide, which has been described as either a low affinity weak partial agonist or antagonist of the GLP-1R [17], [18] and that GLP-1 936 amide can be present at five- to ten-fold higher concentrations than GLP-1 736 amide [10], the present study examined potential interactions between compound 2 and GLP-1 936 amide at the GLP-1R