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We found 21 BDHI-liganded sites among the top 150 most reactive cysteine residues identified from previous study, 25 including the active site cysteines of glutathione S -transferase omega-1 (GSTO1) and methylated DNA protein cysteine methyltransferase (MGMT) (Figure S6B)

Finally, the horizons and challenges in current and future research areas are also speculated upon

As we get older, our cells begin to lose their ability to repair themselves

In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]