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It was also concluded that the use of an antiseptic mouthwash, or anything else that disrupts the oral microbiome, will disrupt the conversion of beetroot nitrates into nitrites to reduce the effectiveness of beetroot production with potential negative impacts on cardiovascular health and exercise performance

doi: 10.1186/s12931-019-1164-1 155 CuiJWangYTianXMiaoYMaLZhangCet al

Bonora M et al (2017) Mitochondrial permeability transition involves dissociation of F 1 F O ATP synthase dimers and C-ring conformation

Keeping detailed records of dosing, timing, and symptom changes helps optimize personal protocols over time