ADVERSE REACTIONS: As mentioned above, hepatotoxicity has occurred with kava use.[15] Urticaria has been reported following consumption of kava.[16] Kava overdose resulted in altered mental status and ataxia.[17] Reversible kava dermopathy characterized by a scaly eruption has been reported in heavy kava drinkers.[18] HERB-DRUG INTERACTIONS: Kava may have additive effects when administered concurrently with benzodiazepines.[19] Kava inhibits cytochrome P450 2E1, 1A2, and 2D6, and can affect the metabolism of drugs that are metabolized by these enzymes.[20-22] Kava may potentiate the sedative effects of anesthetics.[23] TAKE HOME POINTS For additional information, visit the Memorial Sloan-Kettering Cancer Center Integrative Medicine Service website, "About Herbs," at
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The contradictory response of glutathione gel in the treatment of melasma in different studies may be attributed to the difference in stability, absorption, penetration of glutathione and affected by the different vehicle (soap, cream, gel or lotion) rather than the efficacy of glutathione itself
Store at room temperature between 59F to 86F (15C to 30C), away from heat, moisture, and direct light