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Rapid weight gain due to fluid retention Loss of appetite Need to urinate at night Waking up after a few hours of sleep due to shortness of breath What are the causes of congestive heart failure
GLP-1 receptor agonists significantly lowered CRP levels (standardised mean difference of 0.39) and TNF- levels (SMD of 0.51), with longer treatment durations yielding more noticeable benefits, according to a thorough meta-analysis published in 2025 that synthesised 25 studies involving 1,878 patients with type 2 diabetes
41 This means that exclusively blocking IL-23p19 results in more direct and stronger inhibition of inflammation with no diverse effects on Th1/Th17 regulation
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