A 2026 UK review of how HGF activates repair Schwann cells (Ko 2018, Scientific Reports ), the 2021 rat sciatic-nerve study where Dihexa + stem cells improved motor recovery, the VM202 / Engensis HGF gene-therapy Phase 3 in painful diabetic peripheral neuropathy (results posted Jan 2025), chemotherapy-induced neuropathy (CIPN) and the duloxetine question, and the 2026 AthiraLeonaBio pivot taking the oral HGF/MET modulator ATH-1105 into ALS with an honest account of why Dihexa still has zero human neuropathy data Read the full review Neuroscience 27 May 2026 Dihexa for Migraine & Chronic Migraine: The 2026 UK Review Rigorous 2026 UK review of Dihexa for migraine and chronic migraine
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Neurological symptoms are among the most clinically significant and may include: Tingling, numbness, or a 'pins and needles' sensation in the hands and feet Difficulty with balance and coordination (sensory ataxia) Memory problems, cognitive slowing, or confusion Mood changes, including low mood or irritability Haematological symptoms may include: Persistent fatigue and weakness Breathlessness on exertion Pallor or a slightly yellowish tinge to the skin A sore, inflamed tongue (glossitis) It is worth emphasising that neurological damage from B12 deficiency including subacute combined degeneration of the spinal cord can progress and become irreversible if treatment is delayed, even in cases where anaemia is absent
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