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Failure to comply, say the drugmakers, will result in civil litigation and referral to regulatory authorities

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In human cell culture studies, increased expressions of PAI-1 and VCAM-1 have been reported to be associated with hyperglycemia-related endothelial cell dysfunction, a process that predisposes vasculature to accelerated atherogenesis 52

Los riesgos significativos asociados a los agonistas del receptor IGF-1 incluyendo hipoglucemia, promocin del cncer y efectos acromeglicos aplican al DES IGF-1 y se discuten en este artculo