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This creates a powerful body recomposition effect: fat mass decreases, muscle density improves, insulin sensitivity increases, and overall metabolic flexibility is restored

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In a prospective cohort study of 36 patients with albuminuria who were initiated on sitagliptin 50 mg daily, patients experienced a significant change in both systolic and diastolic BP that was apparent after 6 months (baseline systolic BP 140 +/ 18 mmHg dropped to 129 +/ 17 mmHg and baseline diastolic BP 77 +/ 10 mmHg fell to 73 +/ 7 mmHg

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration