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Although leading drug interaction texts differ in the potential for an interaction between phentermine and this group of antihypertensive agents, these effects are likely to be clinically significant and have been described in hypertensive patients on these medications

The convergence of bile acid-FXR/TGR5 signaling, microbial metabolite-driven adipocyte gene programs, and central neuroendocrine control establishes a microbiota-gut-brain-adipose axis through which GLP-1RAs support healthy AT remodeling, WAT beiging, and overall metabolic balance [144,145]