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It is clear that the CNS is necessary for GLP-1R mediated induction of visceral illness as mice with a CNS deletion of the GLP-1R develop conditioned taste aversion (CTA) to lithium chloride but not to liraglutide (Sisley et al., 2014)

Retatrutide versus tirzepatide This comparison is particularly relevant because tirzepatide already demonstrated significant improvements over semaglutide, making it the standard that retatrutide must beat

GLP-1 receptor activation slows gastric emptying, creating a plausible biological basis for acid reflux and heartburn symptoms

shared his experience: Thanksgiving used to be my excuse to binge-eat