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The UK Chief Medical Officers' guidelines recommend at least 150 minutes of moderate-intensity aerobic activity weekly, supplemented with muscle-strengthening exercises on two or more days
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No major safety concerns were reported
On the contrary, depleting central 5-HT in rodents leads to a reduction in thermoregulation, a marked decrease in uncoupling protein 1 expression in brown and white adipose tissue, and a sharp increase in blood glucose, free fatty acids and triglycerides [53]
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