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Importantly, the activity of GSK3 is suppressed at the leading edge of migrating cells, which allows these MAPs to bind and stabilize microtubules at the cell cortex [56]
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If a patient is fortunate enough to seek out and obtain early medical attention (typically within 4 hours of the acute APAP ingestion), activated charcoal can be effective in limiting drug absorption, unless there are obvious contraindications, such as an unprotected airway or compromise of the gastrointestinal tract
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