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Key mechanisms include systemic communication, brain-kidney interactions, gut-kidney interactions, and integrated gut-brain-kidney signals (Figure 1)

The most important question is not simply, Which treatment is newest? The better question is, Which treatment gives me the safest, most realistic, and most durable chance of success? Bottom line: GLP-1 pills may be a helpful option for many patients, especially those who want to avoid injections

The EXAMINE and SAVOR-TIMI 53 studies were excluded from sensitivity analyses because DPP-IV inhibitor drugs did not show CV benefit in their individual trials