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It is a tumor suppressor gene that plays a significant tumor-suppressive role in hepatocellular carcinoma and prostate ca 34,35

However, when excessive amounts of acetaminophen are ingested, the livers supply of glutathione can be depleted rapidly, leaving NAPQI unneutralized.[ref] Glutathione is the master antioxidant, but there are several situations in which glutathione levels may already be low and thus unable to rise to the occasion for high doses of acetaminophen

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sequence GEPPPGKPADDAGLV) originally characterised during research into protective components of gastric juice.[1] Its stability and broad tissue interactions have made it a focus in models of gut injury, tendon and ligament damage, vascular integrity, and neuroprotection