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In hepatocellular carcinoma, FBXO7 indirectly suppresses the PRMT1-mediated methylation and activation of PHGDH by promoting the ubiquitination and degradation of PRMT1, thereby inhibiting serine synthesis and tumor growth ( Figure 3 Multiple E3 ubiquitin ligases influence SSP activity by regulating the stability of PHGDH, the rate-limiting enzyme of the pathway ( Argininosuccinate synthase 1 (ASS1) functions as a tumor suppressor in triple-negative breast cancer (TNBC)
Glutamatergic enteric neurons
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Heat acts as a catalyst for all of these destructive processes
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