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Abstract Glycyl-L-histidyl-L-lysinecopper (GHK-Cu), an endogenous tripeptidemetal complex, has attracted increasing interest due to its multifaceted biological roles in tissue repair, anti-inflammatory regulation, extracellular matrix remodeling, and redox homeostasis

However, reported performance is platform- and cohort-dependent and should be interpreted as supportive evidence for multimarker modelling rather than as a clinic-agnostic benchmark, pending calibration and external validation across laboratories and protocols

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