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Clinical trials did not specify a relationship to meals, and absorption occurs through subcutaneous tissue, not the GI tract, so food in your stomach has no direct effect on how the drug enters your bloodstream

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Sensitivity changes: Areas that have become either numb or excessively tender compared to surrounding skin may have nerve irritation

A person who loses 50 pounds with semaglutide plus resistance training will have a dramatically different body composition, metabolic rate, and long-term outcome than someone who loses 50 pounds with semaglutide alone