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Reactive oxygen species (ROS) or free radicals cause damage to key cellular components like DNA, RNA, lipids, proteins, and structural membranes

In contrast, mice injected with MDCK-NPs, displayed significant anomalies in white blood cell (WBC), eosinophil (EOS), basophil (BAS) and platelet (PLT) counts, indicating that MDCK cell membranes could trigger an immune response, which is presumably related to MDCK-NP-induced death in mice