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Available at: 39 World Health Organization (2022)

Both routes have a place

APAP hepatotoxicity occurs through formation of the noxious NAPQI metabolite, which is present in excessive quantities, as augmented by features of glutathione (GSH) depletion, oxidative stress and mitochondrial dysfunction leading to depletion in adenosine triphosphate (ATP) stores

While more research is needed, studies have shown that glutathione supplementation may have a beneficial effect on lupus patients by reducing disease activity