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PRP therapy has been extensively studied as a minimally invasive alternative to corticosteroid injections and surgical interventions: A landmark RCT found that PRP injections resulted in significant pain relief and functional improvements compared to corticosteroids at 6-month and 1-year follow-ups (PMID: 19797698)

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According to it, new skin cells form deep inside the skin and move upward until old cells are shed from the surface

Replace devices according to manufacturer recommendations