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doi:10.1016/S0969-2126(00)00104-0 ^ a b c Harvey R.A., Ferrier D.R

Intrahepatic and perihilar cholangiocarcinomas are about 1.5-fold more common in men, whereas gallbladder carcinoma is two- to six-fold more frequent in women (Ghidini et al., 2019)

The function of VDR depends not only on ligand binding with 1,25-dihydroxyVitamin D but also on its dynamic interactions with coactivators (e.g., SRC-1, DRIP205/MED1), epigenetic enzymes (e.g., HDACs, LSD1, PRMT5), and corepressor/de-repressor complexes (e.g., NCoR/SMRT), which are recruited and reorganized in a ligand-inducible manner to mediate precise gene regulation [113,114,115]

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