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Transfection of Cyp2E1 [145] or induction of Cyp2E1 by dimethyl sulfoxide (DMSO) [139], can restore at least in part the metabolic capacity of HepG2 cells but the overall gene expression profile of HepG2 cells shows low similarity to primary human hepatocytes [146, 147]

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How it transforms your skin: Visibly fades dark spots, post-acne marks, and sun-induced pigmentation

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This was revealed through analysis using the Broad Institute's Connectivity Map, a database of gene expression responses to known compounds

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