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Several study limitations warrant acknowledgment, including controlled laboratory conditions that may not reflect field environments, short-term exposure effects without addressing potential resistance development, and lack of evaluation of effects on beneficial insects and soil microorganisms

A 33-year-old female presented a painless pigmented dark-brown macule, with evolution time of two years, on palatine attached gingiva of maxillary right first molar, and measured 0,6 cm in maximum diameter (Case 3)

100% with 30% reduction), normalization of ALT in 79% of those who had it elevated, and improvements in non-invasive markers of fibrosis 22