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In several robust trials, a marked decrease in the incidence of acute respiratory disease, ischemic heart disease, hypertension disease, pulmonary fibrosis, coronary artery disease, diabetes mellitus, Alzeimers disease, deforming osteoarthrosis, and osteoporosis was observed as compared to control animals 6

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By in-depth analysis of the advantages and challenges faced by the multi-target intervention of natural products, this review is expected to provide a new perspective for in-depth understanding of the complex pathophysiology of PH, and offer theoretical basis and ideas for the development of new therapeutic strategies based on natural products, which are intended to reverse immune-metabolic imbalance and vascular remodeling