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C32 and C88 in PfGrx) could not only form an intramolecular disulfide during catalysis or affect the reactivity of the active-site thiolate but also function as a resolving cysteine for trapped Grx(SSR) species (Fig

Options for vitamin B12 treatment include: Depending on the cause of the deficiency, you may only need treatment until your vitamin B12 levels are back to normal, or you may need B12 therapy for the rest of your life

Nat Rev Mol Cell Biol 22:266282 Lv M, Cai Y, Hou W, Peng K, Xu K, Lu C et al (2022) The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes

Vitamin B12 plays an important role in the production of myelin, a fatty substance that surrounds your nerves, insulating and protecting them