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While weve learned a great deal about Delta sleep inducing peptide since its discovery, there are still many unanswered questions regarding its production and distribution throughout the body

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At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]