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Some participants achieved substantial weight reductions

Bottom line: A healthy gut requires a multi-faceted approach

Among them, SIRT1 is the most studied for its role in fat metabolism, muscle preservation, and mitochondrial health

A 2018 meta-analysis of 17 randomized controlled trials found that ALA supplementation significantly reduced total cholesterol, LDL-C, and triglycerides, though it had no consistent effect on HDL-C