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Name: less side effects semaglutide or tirzepatide Comparative safety and of and tirzepatide: Implications for clinical decision-making in obesity management Semaglutide and Tirzepatide have taken
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53,89,92,95 It has been speculated that the gut microbiome metabolizes glucose in the colon to form SCFA, which bind to free fatty acid receptors (FFAR2/3) on distal small intestine L cells and may promote sustained GLP-1 release

It is worth mentioning that some microbiota also plays a role in stabilizing thyroid hormone fluctuations and improving the utilization of levothyroxine