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The derivatives with corresponding R -configuration were postulated to be essentially inactive in all cases

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4.1.3 Inhibition of melanin synthesis by mediating MITF-related pathway It regulates the transcription of tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), activates various target genes related to melanin synthesis, and influences the reproduction, proliferation, and survival of melanogenic cells (Wellbrock and Marais, 2005

While results are promising, the product still lacks peer-reviewed clinical data and formal regulatory approval, so users are advised to consult qualified practitioners and maintain realistic expectations