A current, five-year clinical trial is studying the long-term effects of semaglutides and diabetic eye disease in 1,500 people, which should tell us more about the ocular risks in the future
5.3 Inhibition of free fatty acid key target TLRs FAs promote the development of GA and trigger the initiation of inflammation, mainly by activating its downstream key targets TLR2/TLR4 ( In addition to the drugs that ameliorate inflammation in GA by targeting TLRs, sparsolonin B inhibited FA-induced macrophage inflammation in an osteoarthritis model by selectively blocking the TLR4/MD-2/NF-B axis (209)
Indeed, in more extreme cases with very aggressive inflammatory activity, a total reset of the patients immune system by autologous bone marrow transplantation has shown remarkable efficacy at stopping new relapses or MRI lesions and even modestly reversing clinical disability (Rush et al., 2019), though currently this aggressive intervention is recommended only for patients with very active inflammatory disease (Miller et al., 2021)
Injection-related injuries pose another significant threat
