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Similar changes have been observed in the lung which is also characterized by evidence of increased oxidative stress including glutathione depletion, a shift to alternative methods of energy production, and reduced levels of ATP 15

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Leipnitz G, Vargas CR, Wajner M (2015) Disturbance of redox homeostasis as a contributing underlying pathomechanism of brain and liver alterations in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency

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