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Aleniglipron (Structure Therapeutics) -- Phase 2# Aleniglipron has produced the most competitive oral weight loss data to date: ACCESS: 11.3% placebo-adjusted weight loss at 36 weeks (120 mg) ACCESS II: 15.3% placebo-adjusted weight loss at 36 weeks (240 mg) Low-dose initiation (2.5 mg) significantly improved tolerability Phase 3 planned for mid-2026 At 36 weeks, aleniglipron's trajectory suggests it could approach injectable-level efficacy with longer treatment duration

Furthermore, native GIP has negligible affinity for the GLP-1 receptor (GLP-1R)

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Reducciones de esta magnitud son poco comunes en la medicina de las adicciones, y lo notable es que provienen de medicamentos diseados inicialmente para la diabetes, posteriormente reutilizados para la obesidad y nunca pensados para tratar adicciones