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In addition, the guidelines were the first time the AAP issued comprehensive recommendations for how pediatricians should approach obesity treatment

S., Schoenfeld, B

HDLs benefit to endothelial cells is largely mediated by cell signaling through phosphatidylinositol 3-kinase (PI3K) and Akt and is induced by bioactive lipids and associated proteins on HDL, including lysosulfatide, S1P, and sphingosylphosphorylcholine (SPC) (791,798,806)