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Clin Sci (London England: 1979)

Zofran highlights of prescribing information, U.S

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

If your diabetes is advanced, you may still need to take insulin or another medication. But if you are already taking insulin, you may be able to decrease your dose (or maybe stop it completely) if taking a GLP-1 agonist is effective, Neumiller says