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[DOI] [PubMed] [Google Scholar] 355.Thomson CD

Sulforaphane, a compound found in cruciferous vegetables, was validated to activate the Nrf2/ARE pathway and inhibit NF-B pathway, thereby providing antioxidant and anti-inflammatory effects that are beneficial in DN models (Negi et al., 2011b)

The dose escalation schedule spans 16 to 20 weeks: 0.25 mg for four weeks, 0.5 mg for four weeks, 1.0 mg for four weeks, 1.7 mg for four weeks, and finally 2.4 mg as the maintenance dose