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Based on TCM theory, the pathogenesis of CKD is complex, in that CKD is considered to be the consequence of an assault from both internal and external evils (i.e., pathogenic factors), which further leads to the imbalance of Yin and Yang function in the body ( Methodology A systemic search of PubMed, CNKI, and Google Scholar was conducted to collect all available articles in English or Chinese that are related to the Chinese Yang/Qi-invigorating tonic botanical drugs/herbal formulations applied in the treatment of CKD, and their effects on mitochondrial function

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