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[] Interestingly, mutation in single-minded family basic-helix-loop-helix transcription factor 1 (SIM1), a transcription factor critical for hypothalamus development, causes PWS-like phenotypes featuring paraventricular nucleus (PVN) neuron reduction, disrupted MC4R signaling, and profound satiety impairment

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These profound effects on brain structure and function position Dihexa as a promising candidate for cognitive enhancement and the regeneration of neural networks compromised by injury or disease

Novo also collaborates with academia and biotech firms for innovation (examples: partnerships with MIT on RNAi delivery, acquisitions like Dicerna for RNAi, and an alliance with Emisphere to develop oral semaglutides absorption technology)