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These stimulate intestinal L-cells through nutrient sensing and short-chain fatty acid production from bacterial fermentation

It does mean the evidence base for a specific compounded preparation is different from the evidence base for an FDA-approved finished drug product

SubMagna is sold by the Professional Compounding Centers of America (PCCA), which conducted proof-of-concept studies showing that, when added to semaglutide, it was absorbed by human oral tissues in a lab dish and was detectable in the blood plasma of mice after administration

An interesting question is whether one of these hormones contributes more to tirzepatides effects than the other