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Although several studies have demonstrated the efficacy of RSL3 in various animal models ( in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population ( In summary, we studied the characteristics of CRC DTP cells derived from the chemotherapy or targeted agents, and the effects of ferroptosis on persister cells

Although these approaches are still in experimental stages, they could potentially correct underlying genetic abnormalities or promote neural regeneration